Sox4 chip
WebInterestingly, ChIP-seq assays revealed that 70.4% of SOX4 peak summits were within 50bp of the RELA peak summits suggesting that both proteins bind in close-proximity on regulatory sequences ... Web27. sep 2024 · Notably, SOX4 is a direct target gene of C-MYC; C-MYC activates SOX4 expression via binding to its promoter. In addition, Co-IP analysis demonstrated a physical …
Sox4 chip
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Web5. júl 2012 · Sox4 overexpression enhances survival and cell-cycle progression of mouse bone marrow cells in vitro. (A) Flow cytometry analysis of retrovirally transduced and … http://ko.cwru.edu/publications/ramezani-rad.pdf
Web1. dec 2024 · SOX4 has also been reported to regulate gliogenesis, as prolonged expression of a SOX4 transgene under the control of the human GFAP promoter activating transgene … WebChIP-qPCR, FAIRE assay and luciferase reporter assays were used to investigate transcriptional regulation. Results: ... Scramble and shPPARγ beige adipocytes (day 6) were transfected with Flag-Sox4 and 2 days later subjected to ChIP assay by using IgG or …
Web10. nov 2008 · SOX4 is a critical developmental transcription factor in vertebrates and is required for precise differentiation and proliferation in multiple tissues. In addition, SOX4 is overexpressed in many human malignancies, but the precise role of SOX4 in cancer progression is not well understood. Here we have identified the direct transcriptional … Web22. apr 2024 · SOX4 and RELA Function as Transcriptional Partners to Regulate the Expression of TNF- Responsive Genes in Fibroblast-Like Synoviocytes SOX4 and RELA …
WebSOX4 is a transcription factor with pleiotropic functions required for different developmental processes, such as corticogenesis. As with all SOX proteins, it contains a conserved high mobility group (HMG) and exerts its function via interaction with other transcription factors, such as POU3F2. Recently, pathogenic SOX4 variants have been identified in several …
Web16. máj 2024 · In order to determine whether SOX4 binds to the promoter of p65, a CHIP-PCR assay was performed. Our data revealed that SOX4 was able to bind to the p65 promoter at positions +15 to −104, −1490 to −1603, −221 to −318 and −831 to −931 bp. However, the CHIP-PCR assay only indicated that there was a connection between SOX4 … can asthma cause high bpWebEach SOX4 Antibody is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. Our SOX4 Antibodies can be used in a variety of model species: Human. Use the list below to choose the SOX4 Antibody which is most appropriate for your research; you can click on each one to view full technical details ... fish hat crochet patternWebPred 1 dňom · A first reverse transcription is performed and subsequently a second microfluidic chip with microchannels orthogonal to those of the first chip is placed on the slide through which barcode B reagents (B1-Bn ... a process that has been shown to be accompanied by upregulation of renal developmental genes like Sox4. 97 In accordance … can asthma cause heart painWebChIP.Two 90% confluentP150sof bothLNCaP-YFPand LNCaP-YFP/HA-SOX4 or RWPE-1-YFP and RWPE-1-YFP/HA-SOX4 cells were formaldehyde fixed and sonicated, and ChIPassay was performed, as described previously (23). Anti-HA 12CA5 or mouse IgG was used to immunoprecipitate protein-DNA complexes overnight at 4jC and collected using Dynal … fish hatchling definitionWebAs shown in Fig. 5a, our Chip-seq data shows that the same region of Gja1 in intron 1 as found in the SOX2 and SOX4 ChIP experiments is also bound by Tbx3, implicating that it may be a conserved ... can asthma cause high heart rateWebATAC-seq, ChIP-qPCR, and dual-luciferase reporter assays were carried out to verify the role of SOX4/EZH2 in the modulation of METTL3 expression upon TMZ treatment. We demonstrated that TMZ treatment upregulated the expression of the m6 A methyltransferase METTL3, thereby increasing m6 A modification of histone modification … fish hat costumeWeb14. apr 2024 · Gastric cancer. LINC00511 has been shown to promote progression of gstaric acnecr through regulating SOX4 expression and epigenetically suppressing PTEN to induce activity of PI3K/AKT pathway (Wang et al., 2024).Moreover, LINC00511 can promote growth of gastric tumors through acting as a molecular sponge for miR-124-3p and regulating … fishhat inc