WebbA small-molecule allosteric inhibitor of BAX protects against doxorubicin-induced cardiomyopathy. Nature Cancer. doi:10.1038/s43018-020-0039-1 10.1038/s43018-020 … Webb6 mars 2024 · Small-molecule allosteric inhibitors of BAX. Mol. Cell. 2016; 63: 485-497. View in Article Google Scholar; Bombrun A. et al. 3,6-Dibromocarbazole piperazine …
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Webb4 apr. 2024 · Identification of Small-Molecule Bax Inhibitors. To identify novel Bax inhibitors, we screened a collection of 86 compounds based on structures previously … Webb20 maj 2024 · Metabolic reprogramming in cancer cells is controlled by the activation of multiple oncogenic signalling pathways in order to promote macromolecule biosynthesis during rapid proliferation. Cancer cells also need to adapt their metabolism to survive and multiply under the metabolically compromised conditions provided by the tumour … flagtown hillsborough
Identification of potent small molecule allosteric inhibitors of …
Webb29 apr. 2024 · What is claimed is: 1. A method of inhibiting or partially inhibiting activity of one or more PIM (proviral integration site for Moloney murine leukemia virus) kinase(s) comprising contacting a PIM kinase with a compound of Formula (I) or Formula (II) or a pharmaceutically acceptable salt, solvate, hydrate, or N-oxide, prodrug, or isotopic … WebbDesign, synthesis and biological evaluation of pyridine derivatives as selective SHP2 inhibitors. Author links open overlay panel Wen-Shan Liu a b 1, Bing Yang c 1, Rui-Rui Wang a, Wei-Ya Li a, Yang-Chun Ma a, Liang Zhou a, Shan Du a, Ying Ma a, Run-Ling Wang a. Show more. Share. Cite. Webb9 mars 2024 · Chlorothiazide ( 4) is a carbonic anhydrase inhibitor which was introduced in 1958 as a diuretic drug and is used to treat hypertension and edema [ 8, 9 ]. Before the discovery of 4, mercurial drugs associated with severe toxicity were the only available drugs to treat fluid retention. flagtown lofts