Growth arrest specific 6
WebMar 4, 2015 · Growth Arrest-Specific 6 (GAS6) is a vitamin K-dependent protein (VKDP) which is expressed by diverse tissues such as endothelial cells, smooth muscle cells, … WebType 2 diabetes mellitus (T2DM) is a major global health issue. The development of T2DM is gradual and preceded by the pre-diabetes mellitus (pre-DM) stage, which often remains undiagnosed. This study aimed to identify novel pre-DM biomarkers in a high-fat diet (HFD)-induced pre-DM mouse model. Male C57BL/6J mice were fed either a chow diet or HFD …
Growth arrest specific 6
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Growth arrest – specific 6, also known as GAS6, is a human gene coding for the GAS6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts. See more Gas6 is a gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell proliferation. See more Gas6 has been shown to interact with AXL receptor tyrosine kinase, MerTK and TYRO3. The presence of Gla needs a vitamin K-dependent enzymatic reaction that carboxylates the gamma carbon of certain glutamic residues … See more • Maree AO, Jneid H, Palacios IF, Rosenfield K, MacRae CA, Fitzgerald DJ (2007). "Growth arrest specific gene (GAS) 6 modulates … See more WebAim: Gas6 is known to be elevated in sepsis, correlating with the severity of infection and organ failure. We aimed to investigate the performance of Gas6 plasma levels at …
WebJan 12, 2024 · Growth arrest-specific 6 (GAS6) is a vitamin K-dependent protein related to inflammation, fibrosis, as well as platelet function. Genetic ablation of GAS6 in mice protects against cardiac hypertrophy and dysfunction. Nonetheless, the association between plasma GAS6 levels and acute heart failure (AHF) patients is still unknown. We measured … WebApr 15, 2024 · Mechanistically, corticosterone acts on the dermal papillae to suppress the expression of Gas6, a gene that encodes the secreted factor growth arrest specific 6. Restoring Gas6 expression...
WebSep 8, 2024 · The most promising findings up to date acknowledge that both Gas6 and its receptor serum levels (such as sAxl and, probably, sMERTK) have been shown to potentially allow for easy and accurate measurement of hepatic fibrosis progression, also providing indicative parameters of hepatic dysfunction. WebApr 4, 2024 · Gas6 growth arrest specific 6 [ (house mouse)] Gene ID: 14456, updated on 22-Jan-2024. Summary. Enables receptor ligand activity. Acts upstream of or within …
WebMar 29, 2024 · Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma. Mikuteit M, Zschäbitz S, Erlmeier M, Autenrieth M, Weichert W, Hartmann A, Steffens S, Erlmeier …
Webpointed to a secreted protein called growth arrest-specific 6 (GAS6) as a candidate molec - ular messenger. Indeed, delivering GAS6 into the skin using an adenovirus vector (a com-mon tool in gene therapy) not only stimulated hair growth in normal mice, but also restored hair growth during chronic stress or cortico-sterone feeding. hemmings restomodsWebApr 21, 2024 · In the journal Nature [1], an international research group recently published data on a cellular and molecular mechanism that links stress hormones produced by adrenal glands to the activation of... hemmings restoration guidehttp://www.informatics.jax.org/marker/MGI:95660 hemmings real estate for saleWebMar 9, 2024 · The growth-arrest specific 6 (GAS6) protein has emerged in recent years as an attractive target for drug development primarily because it is the sole ligand for the AXL receptor tyrosine kinase, which plays critical roles in cancer, fibrosis, and viral infection. hemmings real estate classifiedWebGrowth arrest-specific 6 (Gas6) encodes the Gas6 protein that binds to TAM receptors (Tyro3, Axl, Mer), resulting in PI3K and Akt pathway activation. 224,225 In platelets, this Gas6 plays a critical role in outside-in signaling, as … land trips to europeWebApr 24, 2024 · Growth arrest-specific gene 6 (Gas6) is a cytokine that binds to receptor tyrosine kinases Tyro3, Axl, and Mer. Numerous studies have suggested that … land trust alliance credit cardsWebFind Mice (IMSR) 24 strains or lines available. Comparison Matrix. Gene Expression + Phenotype. Homozygous null mice are protected against arterial and venous … hemmings row london