Griffithsin virus patent

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August undefined, 2024

WebAug 21, 2024 · For these indications, the annual demand for Griffithsin could reach billions of doses and affordability is paramount. We report the lab-scale validation of a bioprocess that supports production volumes of >20 tons per year at a cost of goods sold below $3,500/kg. Recombinant expression in engineered E. coli enables Griffithsin titers ∼2.5 … WebGriffithsin is a protein isolated from the red algae Griffithsia. It has a 121-amino acid sequence ... As reported in March 2009, Kenneth Palmer and coworkers modified the tobacco mosaic virus to incorporate the griffithsin gene and infected more than 9,300 tobacco plants. They were able to extract enough griffithsin to produce about 100,000 ...

Red Algae Extract Deters Ebola, HIV, SARS and HCV in Studies

WebMay 11, 2024 · 1 Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. 2 Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA. WebCDC tested a broad-spectrum antiviral from a protein found in red alga, Griffitshia sp., that offers a low-cost way to potentially prevent or treat infections from rabies virus. Researchers determined that Griffithsin (GRFT) neutralizes rabies virus (RABV) activity in vitro and in vivo. Currently, with the exception of RIG and another ... swedbank access

(PDF) Griffithsin: An Antiviral Lectin with Outstanding Therapeutic ...

WebOct 24, 2016 · Griffithsin (GRFT), an algae-derived lectin, is one of the most potent viral entry inhibitors discovered to date. It is currently being developed as a microbicide with broad-spectrum activity... WebOn December 1, 2006, the patent was filed and granted – U.S. Patent #US 8088729 B2. The interesting thing here is that the inventors of the patent are listed as: Barry O’Keefe, … WebMay 11, 2024 · Nipah virus (NiV) is a highly pathogenic zoonotic paramyxovirus that causes fatal encephalitis and respiratory disease in humans. There is currently no approved … swedbank access global allt om fonden di

Griffithsin Inhibits Nipah Virus Entry and Fusion and Can …

Prospective Grant of Exclusive Patent License: “Griffithsin ...

WebGriffithsin is moving into clinical trials as an anti-HIV microbicide. Based on the structure of griffithsin and the necessities of pharmaceutical product development and regulatory … WebDec 1, 2006 · US Patent for Anti-viral griffithsin compounds, compositions and methods of use Patent (Patent # 8,088,729 issued January 3, 2012) - Justia Patents Search Anti-viral griffithsin compounds, compositions and methods of use Dec 1, 2006 - The United States of America as represented by the Secretary, Department of Health and Human Services sky says technical fault swedbank ab registry code

"WebJan 6, 2024 · This is a phase 1 study for intranasal application of Q-Griffithsin (Q-GRFT) spray as a prophylactic for severe acute respiratory syndrome-CoV-2. This randomized, placebo-controlled, single site will assess the local and systemic safety of intranasal Q-GRFT after 14 doses in approximately 45 adult participants. " - Griffithsin virus patent

Griffithsin virus patent

Novel Antiviral—Griffithsin Derived from Algae—for Prophylaxis …

WebUS10501507B2 US15/550,323 US201615550323A US10501507B2 US 10501507 B2 US10501507 B2 US 10501507B2 US 201615550323 A US201615550323 A US 201615550323A US 10501507 B2 US10501507 B2 WebJan 23, 2015 · The lectin griffithsin (GRFT) is a potent antiviral agent capable of prevention and treatment of infections caused by a number of enveloped viruses and is currently under development as an anti-HIV microbicide.

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Webgriffithsin seq hiv vector virus Prior art date 2015-02-10 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and … WebDec 9, 2024 · The University of Louisville has received funding from the U.S. Department of Defense (DoD) to develop a nasal spray to prevent serious viral respiratory infections such as COVID-19 using...

WebDec 1, 2006 · A method of inhibiting a viral infection of a host comprising administering to the host an anti-viral griffithsin polypeptide comprising SEQ ID NO: 3 or a fragment … WebFeb 7, 2011 · US Patent for Griffithsin, glycosylation-resistant griffithsin, and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of use Patent (Patent # 8,394,764 issued March 12, 2013) - Justia Patents Search

Requests for copies of the patent applications, inquiries, and comments relating to the contemplated exclusive patent license should be directed to: Taryn Dick, Ph.D., MBA, Licensing and Patenting Manager at Telephone: (301) 631-3007 or Email: [email protected]. See more The National Cancer Institute (NCI), National Institutes of Health, Department of Health and Human Services, is contemplating the grant of an exclusive, sublicensable patent … See more Only written comments and/or applications for a license which are received by the NCI Technology Transfer Center January 12, 2024 will be considered. See more The following and all continuing U.S. and foreign patents/patent applications thereof are the intellectual properties to be licensed under the prospective agreement to ULRF: U.S. … See more WebNov 16, 2024 · Q-Griffithsin (Q-GRFT) nasal spray is an investigational product that has broad spectrum antiviral activity. Q-GRFT is derived from Griffithsin (GRFT) a naturally occurring protein originally isolated from the red alga Griffithsia found in the South Pacific Ocean. For the purposes of this study GRFT has been genetically modified to produce a ...

WebOct 6, 2024 · Virus entry into a susceptible host cell is the first step in the formation of all viral diseases. Controlling viral infections by disrupting viral entry is advantageous for …

WebThis technology describes the lectin, Griffithsin (GRFT), isolated from red algae. GRFT shows significant broad-spectrum anti-viral activity making it a promising agent for use as … swedbank activate cardWebFeb 10, 2016 · Justia Patents US Patent Application for GRIFFITHSIN MUTANTS Patent Application (Application #20240016307) ... If the virus is HIV, then the patients or … swedbank acsessWebFeb 10, 2016 · Justia Patents US Patent for Griffithsin mutants Patent (Patent # 10,501,507) Griffithsin mutants . Feb 10, 2016 - ... invention provides an antiviral … swedbank account openingWebGriffithsin is a mixed specificity lectin, belonging to the Jacalin Lectin family, which binds mannose, glucose, and N-acetylglucosamine. ... Perhaps the greatest biological application of GRFT is as a microbicide for Human Immunodeficiency Virus type-1(HIV-1). GRFT’s antiviral properties arise from its ability to bind to glycoproteins on the ... swedbank antal siffror kontonummerWebIn particular, a red algae-derived griffithsin (GRFT) protein has demonstrated superior in vitro and in vivo antiviral activity with minimum host toxicity against a variety of clinically relevant, enveloped viruses. This review examines the structural characteristics of GRFT, focusing on its carbohydrate-binding capability. swedbank access sverigeWebGriffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide The in vitro efficacy of GRFT revealed low cytotoxicity, high potency, rapid onset of antiviral activity and long-term stability in cervical/vaginal lavage. GRFT is an excellent candidate for anti-HIV microbicide development. swedbank ab share priceWebThe invention relates to an anti-viral Griffithsin polypep tide related conjugates, compositions, nucleic acids, vectors, host cells, antibodies, and methods for their production and SC. BACKGROUND OF THE INVENTION swedbank applications