Forkhead associated domain
WebFeb 20, 2002 · The forkhead-associated (FHA) domain is a small protein module recently shown to recognize phosphothreonine epitopes on proteins. It is present in a diverse … WebApr 10, 2024 · The FOX family contains two domains: a forkhead winged helix–turn–helix DNA binding domain, which directly binds to the promoter region of DNA to regulate gene transcription, and a forkhead-associated (FHA) domain, which interacts with proteins that recognize phosphopeptides .
Forkhead associated domain
Did you know?
WebDec 22, 2004 · We report the characterization of Cep170, a forkhead-associated (FHA) domain protein of previously unknown function. Cep170 was identified in a yeast two-hybrid screen for interactors of Polo-like kinase 1 (Plk1). In human cells, Cep170 is constantly expressed throughout the cell cycle but phosphorylated during mitosis. It interacts with … WebForkhead-associated (FHA) domains are small phosphopeptide recognition modules found in eubacterial and eukaryotic, but not archeal, genomes. Although they were …
WebForkhead box O3 (FOXO3), an essential transcription factor related to liver disease, has been linked to cancer progression. The most frequent primary liver tumor, hepatocellular carcinoma (HCC), has an elevated mortality rate and patient outcomes remain very poor. Here, we examined the diagnostic, prognostic and clinicopathological significance of … WebJul 11, 2024 · The Forkhead box M1 (FoxM1) is one of the most frequently overexpressed transcription factors in many malignant tumors. FoxM1 belongs to the Forkhead Box family, which has a conserved DNA-binding domain responsible for binding of Fox proteins to consensus sites [].Crucially, FoxM1 is expressed in proliferating cells where it …
WebFeb 25, 2024 · found that forkhead-associated domain 2 (FHA2) negatively regulates miRNA biogenesis. It interacts with DCL1 to repress pri-miRNA processing. Remarkably, … WebFeb 28, 2024 · The forkhead-associated (FHA) domain, a well-characterized small protein module that mediates protein-protein interactions by targeting motifs containing …
Webnoun. plural -s. 1. : an arrowhead with two or occasionally three prongs pointing forward. 2. : a forked end of a rod.
WebUsing a two-hybrid screening in yeast, a novel protein, termed Hklp2 (humankinesin-like protein2), was identified and shown to interact with the forkhead-associated (FHA) … pdf to editor freeWebSep 15, 2000 · Using a two-hybrid screening in yeast, a novel protein, termed Hklp2 (humankinesin-like protein2), was identified and shown to interact with the forkhead-associated (FHA) domain of pKi-67. Hklp2 has 1388 amino acids and shows a striking similarity (a 53% identity in amino acids) to Xklp2, a plus-end directed kinesin-like motor … scunci bobby pins for thick hairWebDec 20, 2001 · The forkhead-associated (FHA) domain is a small protein module recently shown to recognize phosphothreonine epitopes on proteins. It is present in a diverse range of proteins in eukaryotic cells, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins, and metabolic enzymes. pdf to edit pdfWebJul 1, 2013 · The crystal structure of the Arabidopsis Dawdle (DDL) forkhead-associated (FHA) domain resembles a canonical FHA domain architecture that recognizes a phosphorylated residue. The arrangement of contacting residues in the crystal packing, together with the functional studies, reveals the mechanism of interaction with DCL1. scunci 52069 portable cordless wet dry vacuumWebThe forkhead-associated (FHA) domain, a protein-phosphoprotein interaction motif with high specificity for phosphothreonine (pThr) residues, has been identified in more than 2000 proteins (from the Pfam database) in prokaryotes and eukaryotes since its discovery in forkhead family transcription factors in 1995 ( 1 ). pdf to editor online freeWebThe Fkh1 Forkhead associated domain promotes ORC binding to a subset of DNA replication origins in budding yeast Nucleic Acids … scunci collection diamond bobby pinsWebMar 24, 2009 · Protein-protein interactions are mediated by distinct regions, or domains, that exhibit varying degrees of specificity in their targets. The forkhead-associated (FHA) domain has the unusual property of distinguishing between phosphorylated serine (pSer) and phosphorylated threonine (pThr) residues in its interaction partners; whereas many … scunci cornrow maker