WebThese NLRP3 modifications include SUMOylation [163][164] [165], nitrosylation [166][167][168], alkylation [169,170], acetylation [171], and dicarboxypropylation, which is a rare modification ... WebDec 1, 2024 · Itaconate alkylates cysteine residues (i.e., 2,3-dicarboxypropylation or itaconation) on kelch-like ECH-associated protein 1 (KEAP1), allowing NRF2 to accumulate and increase the expression of downstream anti-inflammatory genes (such as heme oxygenase 1 and glutathione) and decrease IL-1β and IL-6 transcription in mouse and …
Modification of Proteins by Metabolites in Immunity
WebJul 20, 2024 · These NLRP3 modifications include SUMOylation [163,164,165], nitrosylation [166,167,168], alkylation [169,170], acetylation , and dicarboxypropylation, which is a rare modification mediated by 4-octyl itaconate, a derivative of immunomodulatory metabolite itaconate [172,173]. Collectively, phosphorylation and various PTMs are critical ... WebJun 15, 2024 · The unsaturated dicarboxylic acid structure of itaconate renders it slightly electrophilic and mediates an interaction with thiol functional groups through 2, 3-dicarboxypropylation in the cytosol (Hooftman et al., 2024; Peace and O’Neill, 2024). Itaconate has anti-inflammatory and anti-oxidant properties that have been partly … improve wsa performance
Modification of Proteins by Metabolites in Immunity - Cell
WebJan 18, 2024 · Dicarboxypropylation of C-548 of NLRP3 might be responsible for the disruption of the NLRP3/NEK7 complex observed with OI. Bambouskova et al. … WebDec 1, 2024 · Specifically, itaconate inactived irreversibly the thiol groups of proteins in a process called 2,3-dicarboxypropylation [20]. Several targets of 2,3-dicarboxypropylation have been identified, including Kelch-like ECH-associated protein 1(KEAP1), LDHA, and other enzymes in the glycolytic pathway [21]. WebJun 6, 2024 · The field of immunometabolism has demonstrated that metabolites can lead double lives as immunomodulators. Itaconate is perhaps the best example of such a moonlighting molecule, and has been shown to have multiple anti-inflammatory effects in macrophages. Itaconate is significantly upregulated under inflammatory conditions, and … lithium antipsychotic or mood stabilizer